The chain wants to fill 50,000 new openings at its restaurants across the country in a giant hiring spree on April 19.
Business is booming for the fast food king, and the company wants to add thousands of new Mcstaffers so that more restaurants can stay open 24 hours a day.
The down economy has led to less turnover at restaurants, the company said, and the hiring boom is looking to add between three and four new employees to every McDonalds in the U.S.
The Oak Brook, Ill., company held a similar event in its Western region last year - where more than 60,000 people applied for the 13,000 positions.
Job-hunters can apply in person or online, and some restaurants will hold interviews April 19.
Jan Fields, president of McDonald's U.S.A., told CNN the new hires would increase the U.S. workforce to 700,000.
The average pay of the jobs is $8.30 an hour, and some restaurant mangers can make $50,000 a year, Fields said.